Raising the Diversity of Ugi Reactions Through Selective Alkylations and Allylations of Ugi Adducts.
- Resource Type
- Academic Journal
- Authors
- Zidan A; Laboratoire de Synthèse Organique, CNRS, Ecole Polytechnique, ENSTA ParisTech, UMR 7652, Université Paris-Saclay, Palaiseau, France.; Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.; El-Naggar AM; Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.; Abd El-Sattar NEA; Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.; Ali AK; Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.; El Kaïm L; Laboratoire de Synthèse Organique, CNRS, Ecole Polytechnique, ENSTA ParisTech, UMR 7652, Université Paris-Saclay, Palaiseau, France.
- Source
- Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101627988 Publication Model: eCollection Cited Medium: Print ISSN: 2296-2646 (Print) Linking ISSN: 22962646 NLM ISO Abbreviation: Front Chem Subsets: PubMed not MEDLINE
- Subject
- Language
- English
- ISSN
- 2296-2646
We report here selective Tsuji-Trost type allylation of Ugi adducts using a strategy based on the enhanced nucleophilicity of amide dianions. Ugi adducts derived from aromatic aldehydes were easily allylated at their peptidyl position with allyl acetate in the presence of palladium catalysts. These substitutions were compared to more classical transition metal free allylations using allyl bromides.