Selective vulnerability of inhibitory networks in multiple sclerosis.
- Resource Type
- Academic Journal
- Authors
- Zoupi L; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, EH16 4UU, UK.; Booker SA; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, EH8 9XD, UK.; Simons Initiative for the Developing Brain, University of Edinburgh, Edinburgh, EH8 9XD, UK.; Patrick Wild Centre for Autism Research, University of Edinburgh, Edinburgh, EH8 9XD, UK.; Eigel D; Leibniz-Institut Für Polymerforschung Dresden E.V, Max Bergmann Center of Biomaterials Dresden, Hohe Straße 6, 01069, Dresden, Germany.; Werner C; Leibniz-Institut Für Polymerforschung Dresden E.V, Max Bergmann Center of Biomaterials Dresden, Hohe Straße 6, 01069, Dresden, Germany.; Kind PC; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, EH8 9XD, UK.; Simons Initiative for the Developing Brain, University of Edinburgh, Edinburgh, EH8 9XD, UK.; Patrick Wild Centre for Autism Research, University of Edinburgh, Edinburgh, EH8 9XD, UK.; Spires-Jones TL; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, EH8 9XD, UK.; UK Dementia Research Institute, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Newland B; Leibniz-Institut Für Polymerforschung Dresden E.V, Max Bergmann Center of Biomaterials Dresden, Hohe Straße 6, 01069, Dresden, Germany.; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, CF10 3NB, UK.; Williams AC; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, EH16 4UU, UK. anna.williams@ed.ac.uk.
- Source
- Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE
- Subject
- Language
- English
In multiple sclerosis (MS), a chronic demyelinating disease of the central nervous system, neurodegeneration is detected early in the disease course and is associated with the long-term disability of patients. Neurodegeneration is linked to both inflammation and demyelination, but its exact cause remains unknown. This gap in knowledge contributes to the current lack of treatments for the neurodegenerative phase of MS. Here we ask if neurodegeneration in MS affects specific neuronal components and if it is the result of demyelination. Neuropathological examination of secondary progressive MS motor cortices revealed a selective vulnerability of inhibitory interneurons in MS. The generation of a rodent model of focal subpial cortical demyelination reproduces this selective neurodegeneration providing a new preclinical model for the study of neuroprotective treatments.