Fibrous lesions of the skin and mucous membranes which contain stellate and multinucleated cells.
- Resource Type
- Academic Journal
- Authors
- Regezi JA; Courtney RM; Kerr DA
- Source
- Publisher: Mosby-Year Book Country of Publication: United States NLM ID: 0376406 Publication Model: Print Cited Medium: Print ISSN: 0030-4220 (Print) Linking ISSN: 00304220 NLM ISO Abbreviation: Oral Surg Oral Med Oral Pathol Subsets: MEDLINE
- Subject
- Language
- English
- ISSN
- 0030-4220
Various fibrous lesions of the skin and mucous membranes share the common histologic feature of stellate and multinucleated fibroblasts. These cells are conspicuous under the light microscope because they contain a well-developed, rough endoplasmic reticulum which, because of its high RNA content, stains basophilic. These characteristic cells are a nearly constant feature of the retrocuspid papilla. They are apparent in about half of the fibrous papules of the nose and abundant in about 1 per cent of irritation fibromas. These lesions most likely represent a nonspecific proliferation of the lamina propria or papillary dermis to various stimuli.