Comparison of Multimaterial Decomposition Fat Fraction with DECT and Proton Density Fat Fraction with IDEAL IQ MRI for Quantification of Liver Steatosis in a Population Exposed to Chemotherapy.
- Resource Type
- Academic Journal
- Authors
- Corrias G; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Radiology, University of Cagliari, Italy.; Erta M; Department of Radiology, University of Cagliari, Italy.; Sini M; Department of Radiology, University of Cagliari, Italy.; Sardu C; Department of Medical Science, University of Cagliari, Italy.; Saba L; Department of Radiology, University of Cagliari, Italy.; Mahmood U; Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Huicochea Castellanos S; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Bates D; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Mondanelli N; Orthopedics and Traumatology, University of Siena, Italy.; Thomsen B; GE Healthcare, Chicago, Illinois.; Carollo G; St. John's University, Jamaica, NY, USA.; Sawan P; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Peter Sawan and Lorenzo Mannelli have contributed equally.; Mannelli L; IRCCS SDN, Napoli, Italy.; Peter Sawan and Lorenzo Mannelli have contributed equally.
- Source
- Publisher: Sage Publications Country of Publication: United States NLM ID: 101308899 Publication Model: eCollection Cited Medium: Print ISSN: 1559-3258 (Print) Linking ISSN: 15593258 NLM ISO Abbreviation: Dose Response Subsets: PubMed not MEDLINE
- Subject
- Language
- English
- ISSN
- 1559-3258
Introduction: Oncologic patients who develop chemotherapy-associated liver injury (CALI) secondary to chemotherapy treatment tend to have worse outcomes. Biopsy remains the gold standard for the diagnosis of hepatic steatosis. The purpose of this article is to compare 2 alternatives: Proton-Density-Fat-Fraction (PDFF) MRI and MultiMaterial-Decomposition (MMD) DECT.
Materials and Methods: 49 consecutive oncologic patients treated with Chemotherapy underwent abdominal DECT and abdominal MRI within 2 weeks of each other. Two radiologists tracked Regions of Interest independently both in the PDFF fat maps and in the MMD DECT fat maps. Non-parametric exact Wilcoxon signed rank test and Cohen's K were used to compare the 2 sequences and to evaluate the agreement.
Results: There was no statistically significant difference in the fat fraction measured as a continuous value between PDFF and DECT between 2 readers. Within the same imaging method (PDFF) the degree of agreement based on the k coefficient between reader 1 and reader 2 is 0.88 (p-value < 0.05). Similarly, for single-source DECT(ssDECT) the degree of agreement based on the k coefficient between reader 1 and reader 2 is 0.97 (p-value < 0.05).
Conclusions: The results of this study demonstrate that the hepatic fat fraction of ssDECT with MMD are not significantly different from PDFF. This could be an advantage in an oncological population that undergoes serial CT scans for follow up of chemotherapy response.
Competing Interests: Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
(© The Author(s) 2021.)