Protective Anti-HBs Antibodies and Response to a Booster Dose in Medical Students Vaccinated at Childhood.
- Resource Type
- Academic Journal
- Authors
- Coppeta L; Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy.; Faculty of Medicine, University 'Nostra Signora del Buon Consiglio', Tirana 1000, Albania.; Ferrari C; Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy.; Verno G; Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy.; Somma G; Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy.; Trabucco Aurilio M; Department of Medicine and Health Sciences 'V. Tiberio', University of Molise, 86100 Campobasso, Italy.; Di Giampaolo L; Department of Occupational Medicine, University of Chieti 'G. D'Annunzio', 66100 Chieti, Italy.; Treglia M; Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy.; Magrini A; Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy.; Pietroiusti A; Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy.; Rizza S; Faculty of Medicine, University 'Nostra Signora del Buon Consiglio', Tirana 1000, Albania.; Department of System Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
- Source
- Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101629355 Publication Model: Electronic Cited Medium: Print ISSN: 2076-393X (Print) Linking ISSN: 2076393X NLM ISO Abbreviation: Vaccines (Basel) Subsets: PubMed not MEDLINE
- Subject
- Language
- English
- ISSN
- 2076-393X
The immune system in humans is regulated by the circadian rhythm. Published studies have reported that the time of vaccination is associated with the immune response to vaccine for some pathogens. Our study aimed to evaluate the association between time of dose administration of challenge HBV vaccine and seroconversion for anti-HBs in medical students vaccinated at birth who were found to be unprotected at pre-training screening. Humoral protection for HBV was assessed in 885 medical students vaccinated during childhood. In total, 359 (41.0%) of them showed anti-HBs titer < 10 UI/mL and received a challenge dose of HBV vaccine followed by post-vaccination screening 30-60 days later. The challenge dose elicited a protective immune response (anti-HBs IgG titer > 10 UI/mL) in 295 (83.8%) individuals. Seroconversion was significantly associated with female gender and time of vaccination after controlling for age group and nationality at logistic regression analysis. Students who received the booster dose in the morning had a higher response rate than those who received the vaccine in the afternoon (OR 1.93; 95% C.I. 1.047-3.56: p < 0.05). This finding suggests that morning administration of the HBV booster may result in a better immune response in susceptible individuals.