The enigma of multicentric glioblastoma: physiopathogenic hypothesis and discussion about two cases.
- Resource Type
- Academic Journal
- Authors
- Picart T; a Department of Neurosurgery , Lyon University Hospital-Hospices Civils de Lyon , Bron , France.; Le Corre M; b Department of Neurosurgery, Gui de Chauliac Hospital , Montpellier University Medical Center , Montpellier , France.; Chan-Seng E; b Department of Neurosurgery, Gui de Chauliac Hospital , Montpellier University Medical Center , Montpellier , France.; Cochereau J; b Department of Neurosurgery, Gui de Chauliac Hospital , Montpellier University Medical Center , Montpellier , France.; c Institute for Neuroscience of Montpellier, INSERM U1051 (Plasticity of Central Nervous System, Human Stem Cells and Glial Tumors Research Group), Saint Eloi Hospital , Montpellier University Medical Center , Montpellier , France.; Duffau H; b Department of Neurosurgery, Gui de Chauliac Hospital , Montpellier University Medical Center , Montpellier , France.; c Institute for Neuroscience of Montpellier, INSERM U1051 (Plasticity of Central Nervous System, Human Stem Cells and Glial Tumors Research Group), Saint Eloi Hospital , Montpellier University Medical Center , Montpellier , France.
- Source
- Publisher: Taylor & Francis Country of Publication: England NLM ID: 8800054 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1360-046X (Electronic) Linking ISSN: 02688697 NLM ISO Abbreviation: Br J Neurosurg Subsets: MEDLINE
- Subject
- Language
- English
Two men were admitted following generalized seizures. Cerebral MRI-scans showed multiple independent enhancing lesions which were bilateral (first case) and unilateral but disseminated to the brainstem (second case). Whole-body CT-scans showed no primaries. Both cases were diagnosed by biopsy as IDH1 wild-type multicentric glioblastoma. Treatment of both was palliative. The natural history of this entity remains matter of debate but 2 genomic analysis strikingly revealed that foci from the same patient were of monoclonal origin. Consistently, these 2 cases could sustain the hypothesis that an anatomical connectivity exists between the different foci of a multicentric glioblastoma.