Synthesis of benzodioxinopyrroles as selective alpha 2-adrenoceptor antagonists.
- Resource Type
- Academic Journal
- Authors
- Kitchin J; Department of Medicinal Chemistry, Glaxo-Wellcome, Stevenage, Hertfordshire, UK.; Borthwick AD; Brodie AC; Cherry PC; Crame AJ; Pipe AJ; Procopiou PA; Seaman MA; Turnbull JP
- Source
- Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print Cited Medium: Print ISSN: 0968-0896 (Print) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE
- Subject
- Language
- English
- ISSN
- 0968-0896
A novel series of tetrahydrobenzodioxinopyrroles has been identified as potent and selective alpha 2-adrenoceptor antagonists. Convergent syntheses have been developed that allowed the preparation of analogues and their enantiomers. A compound of particular interest is the 5-fluoro substituted analogue (fluparoxan).