Gain without pain: adaptation and increased virulence of Zika virus in vertebrate host without fitness cost in mosquito vector.
- Resource Type
- Academic Journal
- Authors
- Jaeger AS; Department of Veterinary and Biomedical Sciences, University of Minnesota , Twin Cities, Minnesota, USA.; Marano J; Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University , Blacksburg, Virginia, USA.; Riemersma KK; Department of Pathobiological Sciences, University of Wisconsin-Madison , Madison, Wisconsin, USA.; Castaneda D; Department of Veterinary and Biomedical Sciences, University of Minnesota , Twin Cities, Minnesota, USA.; Pritchard EM; Department of Veterinary and Biomedical Sciences, University of Minnesota , Twin Cities, Minnesota, USA.; Pritchard JC; Department of Veterinary and Biomedical Sciences, University of Minnesota , Twin Cities, Minnesota, USA.; Bohm EK; Department of Veterinary and Biomedical Sciences, University of Minnesota , Twin Cities, Minnesota, USA.; Baczenas JJ; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison , Madison, Wisconsin, USA.; Wisconsin National Primate Research Center, University of Wisconsin-Madison , Madison, Wisconsin, USA.; O'Connor SL; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison , Madison, Wisconsin, USA.; Wisconsin National Primate Research Center, University of Wisconsin-Madison , Madison, Wisconsin, USA.; Weger-Lucarelli J; Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University , Blacksburg, Virginia, USA.; Friedrich TC; Department of Pathobiological Sciences, University of Wisconsin-Madison , Madison, Wisconsin, USA.; Wisconsin National Primate Research Center, University of Wisconsin-Madison , Madison, Wisconsin, USA.; Aliota MT; Department of Veterinary and Biomedical Sciences, University of Minnesota , Twin Cities, Minnesota, USA.
- Source
- Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE
- Subject
- Language
- English
Importance: Previously, we modeled direct transmission chains of Zika virus (ZIKV) by serially passaging ZIKV in mice and mosquitoes and found that direct mouse transmission chains selected for viruses with increased virulence in mice and the acquisition of non-synonymous amino acid substitutions. Here, we show that these same mouse-passaged viruses also maintain fitness and transmission capacity in mosquitoes. We used infectious clone-derived viruses to demonstrate that the substitution in nonstructural protein 4A contributes to increased virulence in mice.
Competing Interests: The authors declare no conflict of interest.