Cyclodextrin metal-organic framework-based protein biocomposites.
- Resource Type
- Academic Journal
- Authors
- Di Palma G; Department of Chemistry, University of California Irvine, Irvine, California 92697, USA. patters3@uci.edu.; Geels S; Department of Physiology and Biophysics, University of California Irvine, Irvine, CA 92697, USA.; Institute for Immunology, University of California Irvine, Irvine, CA 92697, USA.; Carpenter BP; Department of Chemistry, University of California Irvine, Irvine, California 92697, USA. patters3@uci.edu.; Talosig RA; Department of Chemistry, University of California Irvine, Irvine, California 92697, USA. patters3@uci.edu.; Chen C; Department of Chemistry, University of California Irvine, Irvine, California 92697, USA. patters3@uci.edu.; Marangoni F; Department of Physiology and Biophysics, University of California Irvine, Irvine, CA 92697, USA.; Institute for Immunology, University of California Irvine, Irvine, CA 92697, USA.; Patterson JP; Department of Chemistry, University of California Irvine, Irvine, California 92697, USA. patters3@uci.edu.; Department of Materials Science and Engineering, University of California Irvine, Irvine, California 92697, USA.
- Source
- Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101593571 Publication Model: Electronic Cited Medium: Internet ISSN: 2047-4849 (Electronic) Linking ISSN: 20474830 NLM ISO Abbreviation: Biomater Sci Subsets: MEDLINE
- Subject
- Language
- English
Materials are needed to increase the stability and half-life of therapeutic proteins during delivery. These materials should be biocompatible and biodegradable. Here, we demonstrate that enzymes and immunoproteins can be encapsulated inside cyclodextrin based metal-organic frameworks using potassium as the metal node. The release profile can be controlled with the solubility of the cyclodextrin linker. The activity of the proteins after release is determined using catalytic and in vitro assays. The results show that cyclodextrin metal-organic framework-based protein biocomposites are a promising class of materials to deliver therapeutic proteins.