Synthesis and antibacterial activity of new cephalosporines containing a pyrrole ring in the N-acyl chain.
- Resource Type
- Academic Journal
- Authors
- Bijev A; University of Chemical Technology and Metallurgy, Sofia, Bulgaria. a.bijev@uctm.edu; Radev I; Borisova Y
- Source
- Publisher: Govi-Verlag Pharmazautischer Verlag Country of Publication: Germany NLM ID: 9800766 Publication Model: Print Cited Medium: Print ISSN: 0031-7144 (Print) Linking ISSN: 00317144 NLM ISO Abbreviation: Pharmazie Subsets: MEDLINE
- Subject
- Language
- English
- ISSN
- 0031-7144
Nine new cephalosporines containing a pyrrole ring in the N-acyl chain have been synthesized by the N-acylation of 7-ACA or of its 3-analogues via the acid chlorides of substituted 2-pyrrole-carboxylic, -acetic or -propionic acids. H1 NMR and IR data confirming the structure are presented. Preliminary microbiological tests in vitro show significant antibacterial activity, compared with that of cefalexin. Some common structure-activity relationships have been observed.