Sleep Characteristics in Pediatric Anti- N -methyl-d-aspartate (NMDA) Receptor Encephalitis: A Retrospective Cohort Study.
- Resource Type
- Academic Journal
- Authors
- Gombolay G; Department of Pediatric Neurology, Children's Healthcare of Atlanta, Atlanta, GA, USA.; Department of Pediatrics, Division of Neurology, Emory University School of Medicine, Atlanta, GA, USA.; Morris M; Department of Pediatrics, Division of Neurology, Emory University School of Medicine, Atlanta, GA, USA.; Loerinc L; Emory University School of Medicine, Atlanta, GA, USA.; Blackwell L; Department of Pediatrics, Division of Neurology, Emory University School of Medicine, Atlanta, GA, USA.; Department of Pediatric Neuropsychology, Children's Healthcare of Atlanta, Atlanta, GA, USA.; Howarth R; Department of Pediatrics, Division of Neurology, Emory University School of Medicine, Atlanta, GA, USA.; Department of Pediatric Neuropsychology, Children's Healthcare of Atlanta, Atlanta, GA, USA.
- Source
- Publisher: Sage Country of Publication: United States NLM ID: 8606714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1708-8283 (Electronic) Linking ISSN: 08830738 NLM ISO Abbreviation: J Child Neurol Subsets: MEDLINE
- Subject
- Language
- English
Background: Rates of sleep problems in children with anti -N -methyl-d-aspartate (NMDA) receptor encephalitis are unknown. Methods: We used a retrospective observational cohort database of children with a diagnosis of NMDA receptor encephalitis at a single freestanding institution. One-year outcomes were assessed with the pediatric modified Rankin Score (mRS), with 0 to 2 as good and 3 or greater as poor outcome. Results: Ninety-five percent (39/41) of children with NMDA receptor encephalitis had sleep dysfunction at onset; 34% (11/32) reported sleep problems at 1 year. Sleep problems at onset and propofol use were not associated with poor outcomes at 1 year. Poor sleep at 1 year correlated with mRS scores (range 2-5) at 1 year. Discussion: High rates of sleep dysfunction occur in children with NMDA receptor encephalitis. Persistent sleep problems at 1 year may correlate with outcomes as assessed by mRS at 1 year. Further studies comparing the relationship of poor sleep with outcomes in NMDA receptor encephalitis are needed.