Statins increase pathological response in locally advanced rectal cancer treated with chemoradiation: a multicenter experience.
- Resource Type
- Academic Journal
- Authors
- Caputo F; Department of Oncology and Hematology, Division of Oncology, University Hospital of Modena, Modena, 41124, Italy.; Santini C; Department of Oncology and Hematology, Division of Oncology, University Hospital of Modena, Modena, 41124, Italy.; Casadei-Gardini A; Department of Oncology and Hematology, Division of Oncology, University Hospital of Modena, Modena, 41124, Italy.; Cerma K; Department of Oncology and Hematology, Division of Oncology, University Hospital of Modena, Modena, 41124, Italy.; Bardasi C; Department of Oncology and Hematology, Division of Oncology, University Hospital of Modena, Modena, 41124, Italy.; Garajovà I; Medical Oncology Unit, University Hospital of Parma, Parma, 43126, Italy.; Lattanzi E; Radiation Oncology Unit, University Hospital of Parma, Parma, 43126, Italy.; Passardi A; Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Istituto di Ricovero e Cura a Carattere Scientifico, Meldola, 47014, Italy.; Rapposelli IG; Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Istituto di Ricovero e Cura a Carattere Scientifico, Meldola, 47014, Italy.; Spallanzani A; Department of Oncology and Hematology, Division of Oncology, University Hospital of Modena, Modena, 41124, Italy.; Salati M; Department of Oncology and Hematology, Division of Oncology, University Hospital of Modena, Modena, 41124, Italy.; Bonetti LR; Section of Pathology, University Hospital of Modena, Modena, 41124, Italy.; Gelmini R; Department of Surgery, University Hospital of Modena, Modena, 41124, Italy.; Meduri B; Radiotherapy Unit, University Hospital of Modena, Modena, 41124 Italy.; Piccoli M; Department of Surgery, Azienda Ospedaliero-Universitaria of Modena, Ospedale Civile Baggiovara, Modena, 41124, Italy.; Pecchi A; Department of Radiology, University Hospital of Modena, Modena, 41124, Italy.; Benatti S; Department of Oncology and Hematology, Division of Oncology, University Hospital of Modena, Modena, 41124, Italy.; Piacentini F; Department of Medical and Surgical Sciences for Children and Adults, Division of Oncology, University of Modena and Reggio Emilia, Modena, 41124, Italy.; Dominici M; Department of Oncology and Hematology, Division of Oncology, University Hospital of Modena, Modena, 41124, Italy.; Luppi G; Department of Oncology and Hematology, Division of Oncology, University Hospital of Modena, Modena, 41124, Italy.; Gelsomino F; Department of Oncology and Hematology, Division of Oncology, University Hospital of Modena, Modena, 41124, Italy.
- Source
- Publisher: Future Medicine Ltd Country of Publication: England NLM ID: 101256629 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-8301 (Electronic) Linking ISSN: 14796694 NLM ISO Abbreviation: Future Oncol Subsets: MEDLINE
- Subject
- Language
- English
Aims: To investigate the influence of various concomitant medications on outcomes in patients with locally advanced rectal cancer undergoing neoadjuvant chemoradiation. Materials & methods: The authors retrospectively identified 246 patients from 2003 to 2018, collecting demographic and clinicopathological data of interest. Odds ratio (OR) was used to assess the association between concomitant drugs and outcomes. Results: The authors found an association between statins and a Dworak regression grade of 3-4 (OR = 8.78; p = 0.01). Furthermore, statins were significantly associated with more frequent chemoradiation-related toxicity (OR = 2.39; p = 0.0098) and chemotherapy dose reduction or discontinuation (OR = 2.26; p = 0.03). Conclusion: Despite higher frequency of radiotherapy and chemotherapy interruption or dose reduction, the concomitant use of statins during neoadjuvant chemoradiation proved to be associated with better tumor regression.