Why is everyone talking about brain state?
- Resource Type
- Academic Journal
- Authors
- Greene AS; Interdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT 06520, USA; MD/PhD program, Yale School of Medicine, New Haven, CT 06520, USA. Electronic address: abigail.greene@yale.edu.; Horien C; Interdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT 06520, USA; MD/PhD program, Yale School of Medicine, New Haven, CT 06520, USA. Electronic address: corey.horien@yale.edu.; Barson D; Interdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT 06520, USA; MD/PhD program, Yale School of Medicine, New Haven, CT 06520, USA; Department of Neuroscience, Yale School of Medicine, New Haven, CT 06520, USA. Electronic address: daniel.barson@yale.edu.; Scheinost D; Interdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT 06520, USA; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06520, USA; Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, CT 06520, USA; Department of Statistics and Data Science, Yale University, New Haven, CT 06511, USA; Child Study Center, Yale School of Medicine, New Haven, CT 06520, USA.; Constable RT; Interdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT 06520, USA; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06520, USA; Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, CT 06520, USA; Department of Neurosurgery, Yale School of Medicine, New Haven, CT 06520, USA.
- Source
- Publisher: Elsevier Applied Science Publishing Country of Publication: England NLM ID: 7808616 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-108X (Electronic) Linking ISSN: 01662236 NLM ISO Abbreviation: Trends Neurosci Subsets: MEDLINE
- Subject
- Language
- English
The rapid and coordinated propagation of neural activity across the brain provides the foundation for complex behavior and cognition. Technical advances across neuroscience subfields have advanced understanding of these dynamics, but points of convergence are often obscured by semantic differences, creating silos of subfield-specific findings. In this review we describe how a parsimonious conceptualization of brain state as the fundamental building block of whole-brain activity offers a common framework to relate findings across scales and species. We present examples of the diverse techniques commonly used to study brain states associated with physiology and higher-order cognitive processes, and discuss how integration across them will enable a more comprehensive and mechanistic characterization of the neural dynamics that are crucial to survival but are disrupted in disease.
Competing Interests: Declaration of interests The authors declare no competing interests.
(Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)