Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior.
- Resource Type
- Authors
- Barron JJ; Departments of Psychiatry/Weill Institute for Neurosciences.; Biomedical Sciences Graduate Program.; Mroz NM; Biomedical Sciences Graduate Program.; Department of Laboratory Medicine. University of California, San Francisco, San Francisco, CA.; Taloma SE; Departments of Psychiatry/Weill Institute for Neurosciences.; Neuroscience Graduate Program.; Dahlgren MW; Department of Laboratory Medicine. University of California, San Francisco, San Francisco, CA.; Ortiz-Carpena J; Department of Laboratory Medicine. University of California, San Francisco, San Francisco, CA.; Dorman LC; Departments of Psychiatry/Weill Institute for Neurosciences.; Neuroscience Graduate Program.; Vainchtein ID; Departments of Psychiatry/Weill Institute for Neurosciences.; Escoubas CC; Departments of Psychiatry/Weill Institute for Neurosciences.; Molofsky AB; Department of Laboratory Medicine. University of California, San Francisco, San Francisco, CA.; Molofsky AV; Departments of Psychiatry/Weill Institute for Neurosciences.
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- Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
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- Language
- English
The innate immune system plays essential roles in brain synaptic development, and immune dysregulation is implicated in neurodevelopmental diseases. Here we show that a subset of innate lymphocytes (group 2 innate lymphoid cells, ILC2s) is required for cortical inhibitory synapse maturation and adult social behavior. ILC2s expanded in the developing meninges and produced a surge of their canonical cytokine Interleukin-13 (IL-13) between postnatal days 5-15. Loss of ILC2s decreased cortical inhibitory synapse numbers in the postnatal period where as ILC2 transplant was sufficient to increase inhibitory synapse numbers. Deletion of the IL-4/IL-13 receptor ( Il4ra ) from inhibitory neurons phenocopied the reduction inhibitory synapses. Both ILC2 deficient and neuronal Il4ra deficient animals had similar and selective impairments in adult social behavior. These data define a type 2 immune circuit in early life that shapes adult brain function.
Competing Interests: Competing interests: None declared.