The sphinx helps to answer the riddle of cardiac regeneration.
- Resource Type
- Academic Journal
- Authors
- Jung JW; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Hla T; Vascular Biology Program, Boston Children's Hospital and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA.; Arany Z; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: zarany@pennmedicine.upenn.edu.
- Source
- Publisher: Elsevier Science Pub. Co Country of Publication: United States NLM ID: 9001516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3061 (Electronic) Linking ISSN: 10432760 NLM ISO Abbreviation: Trends Endocrinol Metab Subsets: MEDLINE
- Subject
- Language
- English
Cardiomyocyte (CM) death drives heart failure worldwide, and efficient CM regeneration remains a fervently pursued but unachieved goal. Ji and colleagues recently described a novel approach to regeneration by orchestrating divergent sphingolipid signaling pathways in CMs and cardiac fibroblasts (CFs). The findings uncover new biology and offer interesting translational opportunities.
Competing Interests: Declaration of interests T.H. is an inventor on patents and patent applications related to S1P chaperones. The other authors declare no conflicts of interests.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)