Evaluation of Maternal Serum 25-Hydroxyvitamin D, Paraoxonase 1 Levels, and Neutrophil-to-Lymphocyte Ratio in Spontaneous Preterm Birth.
- Resource Type
- Academic Journal
- Authors
- Bozoklu Akkar O; Department of Obstetrics and Gynecology, Cumhuriyet University, Sivas, Turkey.; Sancakdar E; Department of Medical Biochemistry, Cumhuriyet University, Sivas, Turkey.; Karakus S; Department of Obstetrics and Gynecology, Cumhuriyet University, Sivas, Turkey.; Yildiz C; Department of Obstetrics and Gynecology, Cumhuriyet University, Sivas, Turkey.; Akkar I; Department of Pediatrics, Sivas State Hospital, Sivas, Turkey.; Arslan M; Department of Obstetrics and Gynecology, Sivas State Hospital, Sivas, Turkey.; Sahin IO; Department of Pediatrics, Cumhuriyet University, Sivas, Turkey.; Imir Yenicesu AG; Department of Obstetrics and Gynecology, Cumhuriyet University, Sivas, Turkey.; Cetin A; Department of Obstetrics and Gynecology, Cumhuriyet University, Sivas, Turkey.
- Source
- Publisher: International Scientific Information, Inc Country of Publication: United States NLM ID: 9609063 Publication Model: Electronic Cited Medium: Internet ISSN: 1643-3750 (Electronic) Linking ISSN: 12341010 NLM ISO Abbreviation: Med Sci Monit Subsets: MEDLINE
- Subject
- Language
- English
BACKGROUND The aim of this study was to evaluate the association of maternal serum 25-hydroxyvitamin D, paraoxonase 1, and neutrophil-to-lymphocyte ratio in women having early spontaneous preterm birth without clinical chorioamnionitis. MATERIAL AND METHODS This study was prospectively administered in women referred to our obstetrics service with preterm labor that resulted in preterm birth (n=35) and term labor that ended in term birth (n=44). The maternal serum levels of 25-hydroxyvitamin D and paraoxonase 1 were measured and neutrophil-to-lymphocyte ratio was calculated. RESULTS The 25-hydroxyvitamin D and paraoxonase 1 levels of the preterm group were significantly lower than those of the term group (p<0.05). The neutrophil-to-lymphocyte ratio value of the preterm group was significantly higher than that of the term group (p<0.05). There was a significant but small positive correlation between the serum levels of 25-hydroxyvitamin D and paraoxonase 1 in the preterm group (r=0.35; p=0.021). CONCLUSIONS Decreased maternal serum 25-hydroxyvitamin D and paraoxonase 1 levels and increased neutrophil-to-lymphocyte ratio may have a role in the etiology of spontaneous preterm birth.