Antimicrobial silver-filled silica nanorattles with low immunotoxicity in dendritic cells.
- Resource Type
- Academic Journal
- Authors
- Priebe M; Department of Chemistry, University of Fribourg, Fribourg, Switzerland.; Widmer J; Department of Medicine, University of Fribourg, Fribourg, Switzerland.; Suhartha Löwa N; Department of Medicine, University of Fribourg, Fribourg, Switzerland.; Abram SL; Department of Chemistry, University of Fribourg, Fribourg, Switzerland.; Mottas I; Department of Medicine, University of Fribourg, Fribourg, Switzerland.; Woischnig AK; Department of Biomedicine, University Hospital Basel, Basel, Switzerland.; Brunetto PS; Department of Chemistry, University of Fribourg, Fribourg, Switzerland.; Khanna N; Department of Biomedicine, University Hospital Basel, Basel, Switzerland.; Bourquin C; Department of Medicine, University of Fribourg, Fribourg, Switzerland. Electronic address: carole.bourquin@unifr.ch.; Fromm KM; Department of Chemistry, University of Fribourg, Fribourg, Switzerland. Electronic address: katharina.fromm@unifr.ch.
- Source
- Publisher: Elsevier Country of Publication: United States NLM ID: 101233142 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-9642 (Electronic) Linking ISSN: 15499634 NLM ISO Abbreviation: Nanomedicine Subsets: MEDLINE
- Subject
- Language
- English
The progression in the use of orthopedic implants has led to an increase in the absolute number of implant infections, triggering a search for more effective antibacterial coatings. Nanorattles have recently gained interest in biomedical applications such as drug delivery, as encapsulation of the cargo inside the hollow structure provides a physical protection from the surrounding environment. Here, silver-containing silica nanorattles (Ag@SiO 2 ) were evaluated for their antimicrobial potential and for their impact on cells of the immune system. We show that Ag@SiO 2 nanorattles exhibited a clear antibacterial effect against Escherichia coli as well as Staphylococcus aureus found in post-operative infections. Immunotoxicological analyses showed that the particles were taken up through an active phagocytic process by dendritic cells of the immune system and did not affect their viability nor induce unwanted immunological effects. Silver-containing silica nanorattles thus fulfill several prerequisites for an antibacterial coating on surgical implants.
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