Expression of retinoic acid-inducible gene-I in vascular smooth muscle cells stimulated with interferon-γ
- Resource Type
- Article
- Authors
- Imaizumi, Tadaatsu; Yagihashi, Norito; Hatakeyama, Masaharu; Yamashita, Koji; Ishikawa, Akira; Taima, Kageaki; Yoshida, Hidemi; Inoue, Ituro; Fujita, Takashi; Yagihashi, Soroku; Satoh, Kei
- Source
- Life Sciences. Jul2004, Vol. 75 Issue 10, p1171-1180. 10p.
- Subject
- *TRETINOIN
*GENES
*MUSCLE cells
*INTERFERONS
- Language
- ISSN
- 0024-3205
Vascular smooth muscle cells (SMC) play an important role in atherogenesis and vasospasm. Interferon-γ (IFN-γ) is a potent cytokine that regulates immune and inflammatory responses by inducing multiple genes in many types of cells including SMC. Retinoic acid-inducible gene-I (RIG-I) is a putative RNA helicase, but its physiological function is not known. RIG-I is induced in leukemic cells by retinoic acid or in endothelial cells by lipopolysaccharide. We have studied the expression of RIG-I in cultured SMC from human umbilical artery. IFN-γ stimulated SMC to express RIG-I mRNA and protein in concentration- and time-dependent manners. Immunohistochemical analysis revealed the expression of RIG-I in SMC in vivo. We conclude that RIG-I may play some pathophysiological role in immune and inflammatory reactions in SMC. [Copyright &y& Elsevier]