Aim: Phytochemical-based antioxidants have been shown to have cardioprotective effects through reducing or reversing cellular damage. The present study was aimed to evaluate the antioxidant properties of Caesalpinia bonducella leaf extract in cardiac tissue of nicotine-induced experimental rats. Experimental Design: Adult male Wistar rats were used and divided as Group I: Control; Group II: Nicotine-induced rats; Group III: Nicotine-induced rats treated with C. bonducella leaf extract (500 mg/kg body weight/day, orally for 30 days); and Group IV: Control rats treated with C. bonducella (500 mg/kg body weight/day, orally for 30 days). At the end of the treatment, animals were subjected to analyze oxidative stress parameters such as lipid peroxides, hydrogen peroxides (H2O2), hydroxyl radicals (*OH), and lactate dehydrogenase (LDH). Results: In nicotine-induced rats, cardiac marker enzyme LDH level was found to be significantly increased. Similarly, reactive oxygen species such as H2O2 and *OH levels were also found to be raised compared to control. However, C. bonducella leaf ethanolic extract could effectively normalize the abnormal levels of these oxidative stress parameters altered by nicotine toxicity. This preliminary study concludes that C. bonducella has cardiac protective effect. Hence, it can be concluded that C. bonducella may serve as one of the therapeutic options for the management of cardiovascular diseases. [ABSTRACT FROM AUTHOR]