Enantioselective (3+2)-Annulation of β-Keto Esters with Azoalkenes towards Bicyclic Dihydropyrroles via Cooperative Palladium and Brønsted Acid Catalysis.
- Resource Type
- Article
- Authors
- Friedmann, Till; Mireles-Chávez, Daniel A.; Walter, Frederik L.; Schneider, Christoph
- Source
- Synlett. Jun2024, Vol. 35 Issue 9, p997-1000. 4p.
- Subject
- *ANNULATION
*BRONSTED acids
*ESTERS
*PALLADIUM
*CATALYSIS
*ORGANIC chemistry
- Language
- ISSN
- 0936-5214
This article discusses the synthesis of nitrogen-containing heterocycles, which are important in organic chemistry and medicinal chemistry. The authors focus on the enantioselective (3+2)-annulation of β-keto esters with azoalkenes to form bicyclic dihydropyrroles. They propose a cooperative catalysis strategy using a chiral Pd-aqua complex and a Brønsted acid to activate both the nucleophile and the electrophile. The authors successfully demonstrate the synthesis of these heterocycles with high yields and excellent enantioselectivity. [Extracted from the article]