Severe Hypercholesterolemia, Impaired Fat Tolerance, and Advanced Atherosclerosis in Mice Lacking Both Low Density Lipoprotein Receptor-related Protein 5 and Apolipoprotein E.
- Resource Type
- Article
- Authors
- Magoori, Kenta; Man-Jong Kang; Ito, Mitsuko R.; Kakuuchi, Hajime; Ioka, Ryoichi X.; Kamataki, Akihisa; Dong-Ho Kim; Asaba, Hiroshi; Iwasaki, Satoshi; Takei, Yomiko A.; Sasaki, Masako; Usui, Shinichi; Okazaki, Mitsuyo; Takahashi, Sadao; Ono, Masao; Nose, Masato; Sakai, Juro; Fujino, Takahiro; Yamamoto, Tokio T.
- Source
- Journal of Biological Chemistry. 3/28/2003, Vol. 278 Issue 13, p11331. 6p. 1 Color Photograph, 1 Chart, 32 Graphs.
- Subject
- *LOW density lipoproteins
*CHOLESTEROL
*INSULIN
*BLOOD proteins
- Language
- ISSN
- 0021-9258
Demonstrates that low-density lipoprotein receptor-related protein 5 (LRP5) is required for normal cholesterol metabolism and glucose-induced insulin secretion. Comparison of plasma proteins in mice lacking LRP5; Absence of significant effects in the sole LPR5 deficiency; Mediation of both apolipoprotein E-dependent and apolipoprotein E-independent catabolism of plasma lipoproteins by LRP5.