A design optimization study on synthesized nanocrystalline cellulose, evaluation and surface modification as a potential biomaterial for prospective biomedical applications.
- Resource Type
- Article
- Authors
- Ngwabebhoh, Fahanwi Asabuwa; Erdem, Ahmet; Yildiz, Ufuk
- Source
- International Journal of Biological Macromolecules. Jul2018, Vol. 114, p536-546. 11p.
- Subject
- *CELLULOSE
*BIOMATERIALS
*CHEMICAL synthesis
*HYDROLYSIS
*AMINES
- Language
- ISSN
- 0141-8130
In the present study, nanocrystalline cellulose (NCC) was prepared via acid hydrolysis and synthesis parameters were optimized via response surface modelling with a determined maximum NCC yield of 43.8%. The optimized NCC sample was subsequently surface modified via epichlorohydrin-mediated amination forming aminated nanocrystalline cellulose (A-NCC) with an amine content calculated as 1500 μmol/g. The average particle size and zeta potential were determined 100 nm and 325 nm for NCC and A-NCC, respectively. Structural properties were analyzed by FTIR, TEM and XRD techniques. The obtained A-NCC as final product depicted a pKa value of 10.86 ± 0.07 demonstrating favourable protonation of amine groups at physiological pH allowing the material to be suitable for prospective application in drug delivery and tissue engineering. [ABSTRACT FROM AUTHOR]