Evaluation of Leishmania donovani disulfide isomerase as a potential target of cellular immunity against visceral leishmaniasis.
- Resource Type
- Article
- Authors
- Amit, Ajay; Chaudhary, Rajesh; Yadav, Anupam; Suman, Shashi S.; Narayan, Shyam; Das, V.N.R.; Pandey, K.; Singh, S.K.; Singh, Bipin K.; Ali, Vahab; Das, Pradeep; Bimal, Sanjiva
- Source
- Cellular Immunology. May2014, Vol. 289 Issue 1/2, p76-85. 10p.
- Subject
- *PROTEIN disulfide isomerase
*VISCERAL leishmaniasis
*LEISHMANIA donovani
*CELLULAR immunity
*RECOMBINANT proteins
*MOLECULAR size
*PREVENTION
*PATIENTS
*THERAPEUTICS
- Language
- ISSN
- 0008-8749
Highlights: [•] We purified recombinant PDI from Leishmania donovani which was of 15kDa molecular size. [•] r-Ld PDI proved to be virulent factor for LD in VL patients. [•] rLd-PDI caused strong immunosuppression in VL patients. [•] Alanine reduced activities of PDI of Ld and induced collateral protective immunity in VL. [ABSTRACT FROM AUTHOR]