The selection of printing parameters for 3D printing can dramatically affect the dynamic performance of components such as polymer spur gears. In this paper, the performance of 3D printed gears has been optimised using a machine learning process. A genetic algorithm (GA)–based artificial neural network (ANN) multi-parameter regression model was created. There were four print parameters considered in 3D printing process, i.e. printing temperature, printing speed, printing bed temperature and infill percentage. The parameter setting was generated by the Sobol sequence. Moreover, sensitivity analysis was carried out in this paper, and leave-one cross validation was applied to the genetic algorithm-based ANN which showed a relatively accurate performance in predictions and performance optimisation of 3D printed gears. Wear performance of 3D printed gears increased by 3 times after optimised parameter setting was applied during their manufacture. [ABSTRACT FROM AUTHOR]