Background The first Latin-American COVID-19 case was reported in Brazil on February 26, 2020; since then, all regional governments tried to set-up sanitary measures to avoid COVID19 and lower mortality rates among susceptible population. Main goal here is to describe early political decisions and actions on education and healthcare against COVID-19 in five regional countries. Methods Qualitative study based upon intersectoral policy content analysis of bills, plans, and ministry-level documents issued in Argentina, Chile, Brazil, Colombia and Ecuador during February – April 2020; political actions and social reactions as depicted in broad news agencies (CNN, DW) were considered also. Analysis was categorized by three document levels (government, corporate, news), two dimensions (education, healthcare), five measures (quarantine, curfews, social distancing; hands washout, face mask). PDF/DOC/DOCX files were downloaded from their respective webpages, compiled in Google Drive, and analyzed to obtain both emergent categories and compacted texts for integration in a narrative way. Results Emerging categories included political/legal context, rationale, choice of approach against COVID-19, timeline, recurring concepts. Healthcare and education reflected citizens' perception, states' strength, and reactive/proactive congressional or ministerial responses. Lack of preventive measures - laboratory tests, low to none contacts' follow-up, insufficient vaccines/biological products development, and failure in long-term education or science programs triggered a negative cascade effect. Conclusions Depending on each country, there was either compromise on social science to bolster executive management or negation, political polarization, and corruption/corruption of state structures; these issues are complex demanding long-term inter/transdisciplinary approaches solutions against a new pandemic in the future. Key messages Social and political structures and organization have had direct incidence in national response to COVID-19 pandemic. In Latin America, long term research in both health and education is required facing a future new pandemic. [ABSTRACT FROM AUTHOR]