P53-dependent apoptosis suppresses tumor growth and progression in vivo.
- Resource Type
- Article
- Authors
- Symonds, Holly; Krall, Leonard
- Source
- Cell. 8/26/94, Vol. 78 Issue 4, p703. 9p. 12 Color Photographs, 1 Black and White Photograph, 2 Diagrams, 1 Chart, 1 Graph.
- Subject
- *CANCER invasiveness
*GENETICS
- Language
- ISSN
- 0092-8674
Determines the contribution of p53 loss to tumor progression by inducing abnormal proliferation in the brain choroid plexus epithelium of transgenic mice. Effect of the inactivity of p53; Correlation of reduced apoptosis with loss of p53 heterozygosity; Role of p53 in tumorigenesis.