Enantio‐ and Diastereoselective, Complete Hydrogenation of Benzofurans by Cascade Catalysis.
- Resource Type
- Article
- Authors
- Moock, Daniel; Wagener, Tobias; Hu, Tianjiao; Gallagher, Timothy; Glorius, Frank
- Source
- Angewandte Chemie International Edition. 6/7/2021, Vol. 60 Issue 24, p13677-13681. 5p.
- Subject
- *BENZOFURANS
*CATALYSIS
*HYDROGENATION
*HOMOGENEOUS catalysis
*RHODIUM catalysts
*HETEROGENEOUS catalysis
- Language
- ISSN
- 1433-7851
We report an enantio‐ and diastereoselective, complete hydrogenation of multiply substituted benzofurans in a one‐pot cascade catalysis. The developed protocol facilitates the controlled installation of up to six new defined stereocenters and produces architecturally complex octahydrobenzofurans, prevalent in many bioactive molecules. A unique match of a chiral homogeneous ruthenium‐N‐heterocyclic carbene complex and an in situ activated rhodium catalyst from a complex precursor act in sequence to enable the presented process. [ABSTRACT FROM AUTHOR]