Self-aggregation behavior of hydrophobic sodium alginate derivatives in aqueous solution and their application in the nanoencapsulation of acetamiprid.
- Resource Type
- Article
- Authors
- Zhao, Xinyu; Li, Jiacheng; Feng, Yuhong; Yu, Gaobo; Zhou, Qingfeng; He, Furui; Xiao, Dunchao; Chen, Kai; Zhang, Lei
- Source
- International Journal of Biological Macromolecules. Jan2018, Vol. 106, p418-424. 7p.
- Subject
- *SODIUM alginate
*HYDROPHOBIC interactions
*ESTERIFICATION
*AQUEOUS polymeric coatings in pharmaceutical technology
*NEONICOTINOIDS
- Language
- ISSN
- 0141-8130
In this study, cholesteryl-grafted sodium alginate derivatives (CSAD) with different molecular weights were synthesized by esterification. The structure of CSAD was confirmed by FT-IR and 1 H NMR spectrometers. The effects of pH and CSAD polymer concentration on the self-assembled behavior and particle size of CSAD were investigated by fluorescence measurement (FM) and dynamic light scattering (DLS). In the presence of Ca 2+ , the cholesteryl-grafted sodium alginate derivative was used for fabricating self-assembled nanoparticles that can effectively encapsulate the drug acetamiprid. The drug-loaded nanoparticles were characterized by transmission electron microscopy (TEM). The encapsulation efficiency ( EE ) and acetamiprid drug release behavior from the nanoparticles were also studied. The results reveal that CSAD self-assembled nanoparticles had a diameter of 100 nm and were nonaggregated in aqueous media; Moreover, the encapsulation efficiency and the release behavior of nanoparticles were influenced by the MW of CSAD. The mechanism of acetamiprid release was found to vary from non-Fickian (anomalous) to Fickian transport with a decrease in the molecular weight of CSAD. [ABSTRACT FROM AUTHOR]