para‐Selective Palladium‐Catalyzed C−H Difluoroalkylation by Weak Oxazolidinone Assistance.
- Resource Type
- Article
- Authors
- Fang, Xinyue; Tan, Yuqiang; Gu, Linghui; Ackermann, Lutz; Ma, Wenbo
- Source
- ChemCatChem. 4/9/2021, Vol. 13 Issue 7, p1738-1742. 5p.
- Subject
- *CHARGE exchange
*PALLADIUM
*FUNCTIONAL groups
- Language
- ISSN
- 1867-3880
Herein, we report a general and efficient method for the palladium‐catalyzed remote C(sp2)−H difluoroalkylation of N‐aryloxazolidinone derivatives with commercially available difluoroalkyl bromide. This method tolerates a wide range of functional groups with 26 examples in up to 96 % yields. Moreover, it proceeds with complete para‐selectivity. Preliminary mechanistic studies indicated that a single electron transfer process likely involved in this transformation. [ABSTRACT FROM AUTHOR]