FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors.
- Resource Type
- Article
- Authors
- Schroeder, Frederick A.; Chonde, Daniel B.; Riley, Misha M.; Moseley, Christian K.; Granda, Michael L.; Wilson, Colin M.; Wagner, Florence F.; Zhang, Yan-Ling; Gale, Jennifer; Holson, Edward B.; Haggarty, Stephen J.; Hooker, Jacob M.
- Source
- Neuroscience Letters. Aug2013, Vol. 550, p119-124. 6p.
- Subject
- *HISTONE deacetylase inhibitors
*BRAIN physiology
*GLUCOSE in the body
*POSITRON emission tomography
*BRAIN enzymes
*ENZYME activation
- Language
- ISSN
- 0304-3940
Highlights: [•] Rats were treated with histone deacetylase (HDAC) inhibitors for seven days. [•] The two inhibitors used were selective for a subset of class I HDAC enzymes. [•] Treatment resulted in brain glucose uptake changes as measured by PET imaging. [•] The study is the first to image chronic HDAC inhibitor effects using FDG-PET. [Copyright &y& Elsevier]