Asymmetric organocatalytic sulfenylation for the construction of a diheteroatom-bearing tetrasubstituted carbon centre.
- Resource Type
- Article
- Authors
- Tan, Qingfa; Chen, Qianping; Zhu, Zitong; Liu, Xiaohua
- Source
- Chemical Communications. 9/7/2022, Vol. 58 Issue 69, p9686-9689. 4p.
- Subject
- *AMINO acid derivatives
*CARBON
*GUANIDINE
- Language
- ISSN
- 1359-7345
Catalytic enantioselective sulfenylation to construct diheteroatom-bearing carbon centres was achieved by employing chiral guanidine organocatalysts. This protocol provided a facile route towards the synthesis of α-fluoro-α-sulfenyl-β-ketoamides, azlactone adducts and α-sulfur-substituted amino acid derivatives in high yields with good to excellent enantioselectivities. A possible working mode was proposed to elucidate the chiral control of the process. [ABSTRACT FROM AUTHOR]