Copper-catalyzed asymmetric silyl addition to alkenyl-substituted N-heteroarenes.
- Resource Type
- Article
- Authors
- Zeng, Ya-Li; Chen, Bo; Wang, Ya-Ting; He, Cheng-Yu; Mu, Zi-Yuan; Du, Ji-Yuan; He, Long; Chu, Wen-Dao; Liu, Quan-Zhong
- Source
- Chemical Communications. 2/7/2020, Vol. 56 Issue 11, p1693-1696. 4p.
- Subject
- *COPPER catalysts
*DIALKYLZINC
*SILYL ethers
*ALKENES
- Language
- ISSN
- 1359-7345
Asymmetric conjugate addition of PhMe2SiBPin to a wide range of N-heteroaryl alkenes proceeded in the presence of a copper catalyst coordinated with an easily accessible chiral phosphoramidite ligand to afford useful β-silyl N-heteroarenes in high yields (up to 96%) and excellent enantioselectivities (up to 97% ee). [ABSTRACT FROM AUTHOR]