Single-cell multiomics identifies clinically relevant mesenchymal stem-like cells and key regulators for MPNST malignancy.
- Resource Type
- Article
- Authors
- Wu, Lai Man Natalie; Feng Zhang; Rao, Rohit; Adam, Mike; Pollard, Kai; Szabo, Sara; Xuezhao Liu; Belcher, Katie A.; Zaili Luo; Ogurek, Sean; Reilly, Colleen; Xin Zhou; Li Zhang; Rubin, Joshua; Long-sheng Chang; Mei Xin; Jiyang Yu; Suva, Mario; Pratilas, Christine A.; Potter, Steven
- Source
- Science Advances. 11/4/2022, Vol. 8 Issue 44, p1-21. 21p.
- Subject
- *SCHWANN cells
*STEM cell niches
*SCHWANNOMAS
*PLATELET-derived growth factor receptors
- Language
- ISSN
- 2375-2548
The article presents a cancer research on how single-cell multiomics identifies clinically relevant mesenchymal stem-like cells and key regulators for Malignant peripheral nerve sheath tumor (MPNST) malignancy. Topics include underlying principles of tumor cell-state evolution and regulatory circuitries during neurofibromas (NF)-to-MPNST transformation; and pluripotent cells of the neural crest regulated by cell-intrinsic factors that contribute to the establishment of a tumor niche.