Comparison of Immunogenicity Between Inactivated and Live Attenuated Hepatitis A Vaccines Among Young Adults: A 3-Year Follow-up Study.
- Resource Type
- journal article
- Authors
- Xue-en Liu; Hai-ying Chen; Zheng Liao; Yisheng Zhou; Hairong Wen; Shihui Peng; Yan Liu; Rui Li; Jie Li; Hui Zhuang; Liu, Xue-en; Chen, Hai-ying; Liao, Zheng; Zhou, Yisheng; Wen, Hairong; Peng, Shihui; Liu, Yan; Li, Rui; Li, Jie; Zhuang, Hui
- Source
- Journal of Infectious Diseases. 10/15/2015, Vol. 212 Issue 8, p1232-1236. 5p.
- Subject
- *IMMUNOGENETICS
*HEPATITIS A vaccines
*YOUNG adults
*FOLLOW-up studies (Medicine)
*CLINICAL trials
*FISHER exact test
*ONE-way analysis of variance
*HEPATITIS A
*HEPATITIS viruses
*LONGITUDINAL method
*VACCINES
*VIRAL antibodies
*RANDOMIZED controlled trials
*PREVENTION
- Language
- ISSN
- 0022-1899
Unlabelled: A randomized clinical trial of hepatitis A vaccines (1 or 2 doses of inactivated vaccine [Healive] or 1 dose of live attenuated vaccine [Biovac]) was conducted among adults to evaluate seroprotection rates and geometric mean concentrations of antibody against hepatitis A virus for 36 months. High rates of seroprotection persisted for at least 36 months among adults who received 1 or 2 doses of inactivated hepatitis A vaccine but not among adults who received 1 dose of live attenuated hepatitis A vaccine. The long-term serial monitoring of immunogenicity induced by 1 dose of inactivated hepatitis A vaccine is needed to determine an effective alternative to a 2-dose schedule.Clinical Trials Registration: NCT01865968. [ABSTRACT FROM AUTHOR]