Acetate/Alkoxide/Halide Shuttle Systems Mediated by Lewis Acid Catalysts for Insertion Reaction of a One-Carbon Unit into Carbon–Carbon or Carbon–Halogen Bonds.
- Resource Type
- Article
- Authors
- Nishimoto, Yoshihiro; Yasuda, Makoto
- Source
- Synlett. Mar2024, Vol. 35 Issue 4, p367-378. 12p.
- Subject
- *ACID catalysts
*LEWIS acids
*CARBON-carbon bonds
*DIAZO compounds
*CARBOCATIONS
*VAN der Waals clusters
*TRP channels
*ACETATES
- Language
- ISSN
- 0936-5214
This article discusses the insertion reactions of α-diazo esters into carbon-carbon and carbon-halogen bonds using Lewis acid catalysts. The authors provide experimental results and mechanisms for these reactions, demonstrating their effectiveness in achieving desired outcomes. They also explore the scope of different substrates and potential applications of this methodology. The article discusses the use of α-diazo esters in various chemical reactions and proposes that this new strategy may have utility for other challenging reactions involving insertion into carbon-heteroatom bonds. [Extracted from the article]