Neutral merocyanine dyes: for in vivo NIR fluorescence imaging of amyloid-β plaques.
- Resource Type
- Article
- Authors
- Yan, Jin-wu; Zhu, Jia-ying; Zhou, Kai-xiang; Wang, Jin-sheng; Tan, Hui-ya; Xu, Zhong-yong; Chen, Shuo-bin; Lu, Yu-ting; Cui, Meng-chao; Zhang, Lei
- Source
- Chemical Communications. 9/14/2017, Vol. 53 Issue 71, p9910-9913. 4p.
- Subject
- *MEROCYANINES
*CYANINES
*AMYLOID plaque
*AMYLOID beta-protein
*TRANSGENIC mice
- Language
- ISSN
- 1359-7345
Two neutral merocyanine-based near-infrared fluorescent probes were for the first time developed through rational engineering of the classical cationic cyanine scaffold IR-780 for in vivo imaging of amyloid-β plaques. In vivo NIRF imaging revealed that the probe could penetrate the blood–brain barrier and efficiently differentiate the living transgenic and wild-type mice. [ABSTRACT FROM AUTHOR]