Synthesis of P‐Stereogenic Phosphine Oxides via Nickel‐Catalyzed Asymmetric Cross‐Coupling of Secondary Phosphine Oxides with Alkenyl and Aryl Bromides.
- Resource Type
- Article
- Authors
- Wang, Chuanyong; Hu, Xiaobo; Xu, Cheng; Ge, Qiangqiang; Yang, Qingliang; Xiong, Jianqi; Duan, Wei‐Liang
- Source
- Angewandte Chemie. Apr2023, Vol. 135 Issue 15, p1-6. 6p.
- Subject
- *PHOSPHINE oxides
*ARYL bromides
*ALKENYLATION
*ARYLATION
*FUNCTIONAL groups
*KINETIC resolution
- Language
- ISSN
- 0044-8249
A general and mild nickel‐catalyzed enantioselective C(sp2)−P cross‐coupling for synthesizing P‐stereogenic phosphine oxides has been developed. The asymmetric alkenylation/arylation of racemic secondary phosphine oxides with alkenyl/aryl bromides generated P‐stereogenic phosphine oxides with high yields and enantioselectivities. Various functional groups were tolerated, and the applications of this method were demonstrated through late‐stage functionalization and product transformations. [ABSTRACT FROM AUTHOR]