The article discusses a 2019 study on the effect of the topical calcineurin inhibitor tacrolimus on skin microbiome in the skin disease atopic dermatitis (AD) of Thai subjects. Results show that skin microbiome dysbiosis is an important feature of AD in Thais, and that tacrolimus positively impacts skin microbiome in AD. Also noted is the potential of tacrolimus in alleviating AD in the future.