Abstract: ent-Abietane diterpenoids, hebeiabinins A–F (1–5), together with seven known diterpenoids were isolated from leaves of Isodon rubescens var. rubescens. The structures of 1–5 were established on the basis of spectroscopic analyses, including application of 2D NMR spectroscopic techniques. The diterpenoids isolated were evaluated for the cytotoxicity against A549, HT-29, and K562 tumor cells. Compound 5 was the most active with IC50 value of 0.91μM against A549 cells. [Copyright &y& Elsevier]