Background: Infertility is defined as a failure to conceive within one or more years of regular unprotected coitus. It is a medical condition that can cause considerable social, emotional and psychological distress. Objective-To assess the psychosocial problems in the couples with primary infertility attending the infertility clinic, PGIMER, Chandigarh. Material and methods- A descriptive study was conducted at infertility clinic of PGIMER, Chandigarh. 96 couples were enrolled through convenient sampling technique. Data collection was done by interviewing participants using interview schedule consisting of (a) sociodemographic profile, (b) Dyadic Adjustment Scale (DAS) and (c) Depression, Anxiety and stress scale (DASS-21). Results- Most of the couples (90%) were happily married. More than half (58%) of husbands did not experience depression at all, but (40%) of women experienced moderate depression. Two third (68%) of husbands had normal anxiety range but 40% of women experienced extremely severe anxiety. More than half (60%) of couples did not experience any stress. Conclusion- Most of couples were happily married but women experienced more anxiety and depression as compared to men. [ABSTRACT FROM AUTHOR]