This article discusses the case of a 26-year-old female with a 16p12.2 chromosomal deletion who presented with psychosis and other phenotypical features associated with the deletion. The article highlights the role of genetic factors in the development of schizophrenia and the identification of susceptibility loci on chromosome 16. The patient's symptoms and physical characteristics are described, and the possibility of DiGeorge syndrome is considered. The article concludes that this case contributes to the understanding of the genetic basis of schizophrenia and suggests that 16p12.2 deletion should be considered in patients with intellectual disability, facial dysmorphism, congenital anomalies, and psychosis. [Extracted from the article]