Biological Processing of the Cocaine and Amphetamine-regulated Transcript Precursors by Prohormone Convertases, PC2 and PC1/3.
- Resource Type
- Article
- Authors
- Arunangsu Dey; Xiaorong Xhu; Carroll, Raymons; Turck, Christopher W.; Stein, Jeffrey; Steiner, Donald F.
- Source
- Journal of Biological Chemistry. 4/25/2003, Vol. 278 Issue 17, p15007. 8p. 8 Black and White Photographs, 3 Diagrams, 2 Graphs.
- Subject
- *TRANSCRIPTION factors
*COCAINE
*AMPHETAMINES
*NEUROENDOCRINE cells
*PEPTIDES
- Language
- ISSN
- 0021-9258
Demonstrates that cocaine and amphetamine-regulated transcript (CART) as a substrate for the neuroendocrine subtilisin/kexin-like prohormone convertases. Effect of long pro-CART on the rise of an intermediate peptide, residues and two bioactive CART forms through transient transfection studies; Confirmation of the identities of the bioactive and intermediate CART molecules by microsequencing.