The role of CD36 antibodies in haematopoietic stem cell transplantation.
- Resource Type
- Article
- Authors
- Tsuno, Nelson H.; Lozano, Miquel
- Source
- Vox Sanguinis. Jan2024, Vol. 119 Issue 1, p5-7. 3p.
- Subject
- *HEMATOPOIETIC stem cell transplantation
*IMMUNOGLOBULINS
*DISEASE remission
*STEM cell transplantation
*ACUTE myeloid leukemia
*GRAFT versus host disease
- Language
- ISSN
- 0042-9007
This article discusses the role of CD36 antibodies in haematopoietic stem cell transplantation (HSCT). The authors present three cases of CD36-negative patients who developed platelet transfusion refractoriness (PTR) due to CD36 antibodies. The first case did not undergo HSCT due to lack of information on the safety of CD36-incompatible HSCT, while the second and third cases received HSCT from unrelated donors. The authors highlight the importance of managing CD36 antibody titres and suggest strategies such as providing platelet transfusion support from CD36-negative donors or using desensitization protocols before HSCT. They also note the potential role of CD36 antibodies in organ transplantation. [Extracted from the article]