[2+2+1+1] Cycloaddition for de novo Synthesis of Densely Functionalized Phenols.
- Resource Type
- Article
- Authors
- Wei, Wei; Cheung, Ka Key; Lin, Ran; Kong, Lam Cheung; Chan, Ka Lok; Sung, Herman H. Y.; Williams, Ian D.; Tong, Rongbiao; Lin, Zhenyang; Jia, Guochen
- Source
- Angewandte Chemie. 9/4/2023, Vol. 135 Issue 36, p1-7. 7p.
- Subject
- *PHENOLS
*PHENOL
*RING formation (Chemistry)
*ALKYNES
*MOLECULES
- Language
- ISSN
- 0044-8249
A unique benzannulation strategy for regioselective de novo synthesis of densely functionalized phenols is described. Through metal‐mediated formal [2+2+1+1] cycloaddition of two different alkynes and two molecules of CO, a series of densely functionalized phenols were obtained. The benzannulation strategy allows efficient regioselective installation up to five different substituents on a phenol ring. The resulting phenols have a substitution pattern different from those obtained from Dötz and Danheiser benzannulations. [ABSTRACT FROM AUTHOR]