RNA reports breaking news from mitochondria.
- Resource Type
- Article
- Authors
- Tadepalle, Nimesha; Shadel, Gerald S.
- Source
- Molecular Cell. May2021, Vol. 81 Issue 9, p1863-1865. 3p.
- Subject
- *MITOCHONDRIA
*RNA
*IONIZING radiation
- Language
- ISSN
- 1097-2765
Using mitochondria-targeted TALENS and ionizing radiation, consequences of mtDNA double-strand (ds) breaks were investigated by Tigano et al. (2021) who uncovered mtRNA as a retrograde second messenger of this form of mtDNA stress that activates the RIG-I/MAVS innate immune signaling pathway. [ABSTRACT FROM AUTHOR]