X-linked sideroblastic anaemia (XLSA) arises from pathogenic variants in the 5-aminolevulinate synthase 2 (ALAS2) gene, encoding ALAS2. Although dysregulation of the EPO-ERFE-hepcidin axis has been shown for different iron-loading anaemias,[[6], [10]] our findings for the various iron biomarkers suggest ineffective erythropoiesis in well-treated XLSA patients is less obvious. Iron parameters differed among patients, with some patients showing levels outside the reference interval: median ferritin was 154 g/L (IQR 101-317), transferrin saturation (TSAT) 46% (IQR 41-55), and hepcidin/ferritin-ratio was 14.9 pmol/ g (IQR 9.1-27.6). [Extracted from the article]