Apparent Carbon Monoxide Insertion via Double Isocyanide Incorporation during Palladium-Catalyzed Construction of Indoloquinoline Ring in a Single Pot: Synthesis of New Cytotoxic Agents.
- Resource Type
- Article
- Authors
- Nallapati, Suresh Babu; Prasad, Bagineni; Sreenivas, B. Yogi; Sunke, Rajnikanth; Poornachandra, Y.; Kumar, C. Ganesh; Sridhar, B.; Shivashankar, S.; Mukkanti, K.; Pal, Manojit
- Source
- Advanced Synthesis & Catalysis. 11/3/2016, Vol. 358 Issue 21, p3387-3393. 7p.
- Subject
- *CARBON monoxide
*ISOCYANIDES
*PALLADIUM
*AMIDES
*CARBOXAMIDES
- Language
- ISSN
- 1615-4150
The formation of an amide bond via incorporation of two isocyanide units during a palladium-catalyzed construction of the indoloquinoline ring afforded N-substituted 6 H-indolo[2,3- b]quinoline-11-carboxamides as new cytotoxic agents. The solvent and base play a key role in the selective and unprecedented synthesis of this class of amides. [ABSTRACT FROM AUTHOR]