Highlights: [•] The HEM system optimizing nutrient and irrigation increased NUE over farmer's practice by 46–63%, without affecting rice yield. [•] The HYM system optimizing transplanting density and irrigation increased yield by 11% and NUE by 19–89% over farmer's practice. [•] The PRM system optimizing transplanting density, nutrient and irrigation increased yield by 10% and NUE by 51–97% over farmer's practice. [•] Integrated precision crop management has the potential to contribute to both food security and sustainable development. [Copyright &y& Elsevier]