Dynamic contrast enhanced MRI (DCE-MRI) is valuable for evaluating tumor angiogenesis. We aimed to predict the effects of neoadjuvant chemotherapy on breast cancer by DCE-MRI parameters. A total of 162 eligible patients were divided into response and non-response groups. Ktrans, Kep and Ve before, after two courses and at the end of neoadjuvant chemotherapy were compared. ER, PR, HER-2 and Ki-67 expressions in breast cancer tissues were detected by immunohistochemical staining. DCEMRI parameters at different ER, PR and HER-2 expression levels were compared, and their correlations with Ki-67 expression were analyzed. Ktrans and Kep of response group were lower after two courses and at the end of neoadjuvant chemotherapy than those before neoadjuvant chemotherapy (P <0.05). Kep of ER-negative group was higher than that of ER-positive group (P <0.05). Ktrans and Kep of PR-negative group were higher than those of PRpositive group (P <0.05). Kep of HER-2-negative group exceeded that of HER-2-positive group (P <0.05). There were negative correlations between ER expression and Kep, among PR expression, Ktrans and Kep, and between HER-2 expression and Kep (P <0.05). Ki-67 expression was positively correlated with Ktrans and Kep (P <0.05). Ktrans and Kep of TNBC patients were higher and Ve was lower than those of other types. There were significant differences in Ktrans, Kep and Ve among Luminal A, Luminal B and TNBC types (P <0.05). DCE-MRI parameters reflect the biological behaviours of breast cancer, based on which the prognosis of patients can be assessed. [ABSTRACT FROM AUTHOR]