Pathogenesis pathways of idiopathic pulmonary fibrosis in bleomycin-induced lung injury model in mice.
- Resource Type
- Article
- Authors
- Shi, Keyun; Jiang, Jianzhong; Ma, Tieliang; Xie, Jing; Duan, Lirong; Chen, Ruhua; Song, Ping; Yu, Zhixin; Liu, Chao; Zhu, Qin; Zheng, Jinxu
- Source
- Respiratory Physiology & Neurobiology. Jan2014, Vol. 190, p113-117. 5p.
- Subject
- *IDIOPATHIC pulmonary fibrosis
*BLEOMYCIN
*LUNG injuries
*TRANSFORMING growth factors-beta
*SMAD proteins
*INTERLEUKINS
- Language
- ISSN
- 1569-9048
Highlights: [•] We used animal model to research the potential pathogenesis of BLM induced lung injury. [•] Increasing levels of TGF-β1 lead to activated Smad3 bound to the IL-31 promoter region, and the activation of STAT1. [•] The inhibitor of TGF-β1 receptor decreased the IL-31 expression. [•] Knocking-down of IL-31 decreased the STAT1 expression. [ABSTRACT FROM AUTHOR]